San Francisco 49ers: +2. 5 (+130) Philadelphia Eagles: -2. 5 (-150) Over/under: 46 History Lesson The 49ers lead the all-time regular season series between these teams, 19-14-1, but the Eagles have won two of the three most recent meetings. They last faced off back in September 2021, with San Francisco getting the road win in Philly, 17-11, but to be fair it was one of the first games for Sirianni as a head coach and they still had a lot to figure out.

Jason Kelce noted on his podcast earlier in the week, that even before Hurts went out, the game against the Bears wasn’t particularly good, either, so it was good for the team to be back on track. Back on track is even underselling what they did on Saturday night to lock up their spot in the Conference Championship. They’ll have a chance to go out there and do it all again, with what might be the best news of all — none of the Eagles 22 starters were listed on the team’s final injury report heading into this game. That’s incredible! Head coach Nick Sirianni has prioritized player health going all the way back to OTAs and training camp. There was plenty of criticism to go around about the way he lightened the practice load and instead relied on intense walk-throughs. Turns out, Sirianni knew was he was doing.

Eagles vs. 49ers: How to watch, listen and stream NFC